Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheim...
Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease
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United States: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
United States: Cold Spring Harbor Laboratory Press
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Muscle secretes factors during exercise that enhance cognition. Myokine Cathepsin B (Ctsb) is linked to memory function, but its role in neurodegenerative disease is unclear. Here we show that AAV-vector-mediated Ctsb overexpression in skeletal muscle in an Alzheimer's Disease (AD) mouse model (APP/PS1), improves motor coordination, memory function...
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Full title
Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease
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TN_cdi_proquest_journals_3158241515
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3158241515
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ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2025.01.20.633414
