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Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3158241520

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), there is a relative paucity of studies at the protein level. Here, we perform a deep, multi-omic characterization (epigenome, transcriptome and proteome) of HSCs carrying a loss-of-function mutation in Tet2, a key driver of increased se...

Alternative Titles

Full title

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3158241520

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3158241520

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2025.01.20.633881