Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids
Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids
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Author / Creator
Castellanos-Montiel, María José , Franco-Flores, Anna Krystina , Nicouleau, Michael , Haghi, Ghazal , Lépine, Sarah , Baeza, Belén , Chen, Carol X-Q , Taylor Morgan Goldsmith , Aprahamian, Nathalia , Hua, Doris , Chaineau, Mathilde , Gursu, Lale , Abdian, Narges , Deneault, Eric and Thomas Martin Durcan
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
A significant challenge in ALS research is the heterogeneity of the disease. Even mutations within the same gene can lead to different disease prognosis. For instance, in silico protein modeling predicts distinct properties for distinct SOD1 mutations. With this in mind, in this study, we generated and characterized 3D iPSC-derived MN spheroids car...
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Full title
Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids
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Record Identifier
TN_cdi_proquest_journals_3162019498
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3162019498
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ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2025.01.28.635126
