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Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides...

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3165948629

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens

About this item

Full title

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2025-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Natural killer (NK) cells have the unique potential to recognize and kill tumor cells independently of MHC-I presentation of antigens, as well as to secrete cytokines that engage adaptive anti-tumor immunity and the function of cytolytic T cells. We have discovered and characterized chemically synthetic, constrained bicyclic peptides that bind with...

Alternative Titles

Full title

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3165948629

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3165948629

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2024.10.30.621052