The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
About this item
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Author / Creator
Leone, Marina , Eichin, Felix , Kinz, Nadine , Obwegs, David , Sladky, Valentina C , Rizzotto, Dario , Manzl, Claudia , Moos, Katharina , Mergner, Julia , Savko, Clarissa , Giansanti, Piero , Nicole Martinez Garcia , Marques, Margarita M , Jacotot, Etienne D , Boerries, Melanie , Sussman, Mark and Villunger, Andreas
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
The adult mammalian heart is characterized by post-mitotic polyploid cardiomyocytes (CMs). Understanding how CMs regulate cell cycle exit and ploidy can help developing new heart regenerative therapies. Here, we uncover that the PIDDosome, a multi-protein complex activating the endopeptidase Caspase-2, helps to implement a CM-specific differentiati...
Alternative Titles
Full title
The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
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Record Identifier
TN_cdi_proquest_journals_3168488963
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3168488963
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2024.08.27.609375
How to access this item
https://www.proquest.com/docview/3168488963?pq-origsite=primo&accountid=13902
