Abiraterone Acetate for Cushing Syndrome: Study in a Canine Primary Adrenocortical Cell Culture Mode...
Abiraterone Acetate for Cushing Syndrome: Study in a Canine Primary Adrenocortical Cell Culture Model
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United States: Oxford University Press
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English
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United States: Oxford University Press
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Contents
Abiraterone acetate (AA) is a potent inhibitor of steroidogenic enzyme 17α-hydroxylase/17,20-lyase (CYP17A1). AA is approved for the treatment of prostate cancer but could also be used to treat patients with Cushing syndrome (CS). Similar to humans, canine glucocorticoid synthesis requires CYP17A1, providing a useful animal model. The objective of...
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Abiraterone Acetate for Cushing Syndrome: Study in a Canine Primary Adrenocortical Cell Culture Model
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TN_cdi_proquest_journals_3169602869
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3169602869
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ISSN
1945-7170,0013-7227
E-ISSN
1945-7170
DOI
10.1210/en.2018-00588
