APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans
APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans
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England: Oxford University Press
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English
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England: Oxford University Press
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Abstract
Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer’s disease (AD). An extra copy of or gain-of-function mutations in APP correlate with early onset AD. Compared to the othe...
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Full title
APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans
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TN_cdi_proquest_journals_3169734541
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3169734541
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ISSN
2160-1836
E-ISSN
2160-1836
DOI
10.1534/g3.120.401486
