Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpress...
Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila
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United States: Oxford University Press
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English
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United States: Oxford University Press
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Abstract
The human Tar-DNA binding protein, TDP-43, is associated with amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. TDP-43 contains two conserved RNA-binding motifs and has documented roles in RNA metabolism, including pre-mRNA splicing and repression of transcription. Here, using Drosophila melanogaster as a model,...
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Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila
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TN_cdi_proquest_journals_3169745752
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3169745752
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2160-1836
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2160-1836
DOI
10.1534/g3.112.002998
