Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis S...
Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice
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United States: Oxford University Press
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English
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United States: Oxford University Press
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Abstract
Positional cloning of ENU-induced mutations has traditionally relied on analysis of polymorphic variation between two strains. In contrast, the application of whole-genome sequencing (WGS) has enabled gene discovery in mutant lines maintained on an inbred genetic background. This approach utilizes genetic variation derived from ENU-indu...
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Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice
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TN_cdi_proquest_journals_3169761467
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3169761467
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ISSN
2160-1836
E-ISSN
2160-1836
DOI
10.1534/g3.117.300292
