Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of...
Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin
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United States: Oxford University Press
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Language
English
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Publisher
United States: Oxford University Press
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If the fitness effects of amino acid mutations are conditional on genetic background, then mutations can have different effects depending on the sequential order in which they occur during evolutionary transitions in protein function. A key question concerns the fraction of possible mutational pathways connecting alternative functional states that...
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Full title
Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin
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TN_cdi_proquest_journals_3171263188
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3171263188
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ISSN
0737-4038
E-ISSN
1537-1719
DOI
10.1093/molbev/msx085
