Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multi...
Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study
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Author / Creator
Weigand, Isabel , Altieri, Barbara , Lacombe, Amanda M F , Basile, Vittoria , Kircher, Stefan , Landwehr, Laura-Sophie , Schreiner, Jochen , Zerbini, Maria C N , Ronchi, Cristina L , Megerle, Felix , Berruti, Alfredo , Canu, Letizia , Volante, Marco , Paiva, Isabel , Della Casa, Silvia , Sbiera, Silviu , Fassnacht, Martin , Fragoso, Maria Candida B V , Terzolo, Massimo and Kroiss, Matthias
Publisher
US: Oxford University Press
Journal title
Language
English
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Publisher
US: Oxford University Press
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Contents
Abstract
Context
Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20%, and adverse drug effects are frequent. To date, there is no marker established that predicts treatment response. Mitotane has been shown to inhibit sterol-O-acyl transferase 1 (SOAT1), which leads to endoplasmic reticulum stre...
Alternative Titles
Full title
Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study
Authors, Artists and Contributors
Author / Creator
Altieri, Barbara
Lacombe, Amanda M F
Basile, Vittoria
Kircher, Stefan
Landwehr, Laura-Sophie
Schreiner, Jochen
Zerbini, Maria C N
Ronchi, Cristina L
Megerle, Felix
Berruti, Alfredo
Canu, Letizia
Volante, Marco
Paiva, Isabel
Della Casa, Silvia
Sbiera, Silviu
Fassnacht, Martin
Fragoso, Maria Candida B V
Terzolo, Massimo
Kroiss, Matthias
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_3171904703
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3171904703
Other Identifiers
ISSN
0021-972X
E-ISSN
1945-7197
DOI
10.1210/clinem/dgaa293
