Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Cystic fibrosis (CF) pharmacological correctors improve Cystic Fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Several side-effects from these correctors and adverse drug interactions have been reported, emphasizing the need to understand off-targets. We synthesized VU439, a functionalized photoaffinity ligand...
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Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
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TN_cdi_proquest_journals_3171959475
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3171959475
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E-ISSN
2692-8205
DOI
10.1101/2025.02.22.639665
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https://www.proquest.com/docview/3171959475?pq-origsite=primo&accountid=13902
