KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells
KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells
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Author / Creator
Lau, Lena , Henderson, Kurt , Turkoz, Ahu , Linker, Sara , Schlessinger, Dorte , Townsley, Brad , Egan, Brian , Ragunathan, Shoba , Rollins, Robert , Bi, Xianju , Chen, Zhijian J , Brodsky, Oleg , Restaino, Clifford , Gurujan Murali , Jensen-Pergakes, Kristen , Maaarstig, Anders , Chames Kermi , Moore, Paul and Classon, Marie
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Tumors with low expression of Interferon-Stimulated Genes (ISG) and Antigen Presentation (AP) genes respond relatively poorly to current immunotherapies. One of the early hallmarks of cancer is DNA hypomethylation in genomic repeat regions, resulting in the expression of normally silenced endogenous viral elements. Such epigenetic changes have the...
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Full title
KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells
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TN_cdi_proquest_journals_3173169473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3173169473
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2025.02.26.640279
