Chemogenetics defines receptor-mediated functions of short chain free fatty acids
Chemogenetics defines receptor-mediated functions of short chain free fatty acids
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Differentiating actions of short chain fatty acids (SCFAs) at free fatty acid receptor 2 (FFA2) from other free fatty acid-responsive receptors and from non-receptor-mediated effects has been challenging. Using a novel chemogenetic and knock-in strategy, whereby an engineered variant of FFA2 (FFA2-DREADD) that is unresponsive to natural SCFAs but i...
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Full title
Chemogenetics defines receptor-mediated functions of short chain free fatty acids
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TN_cdi_proquest_journals_3186230533
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3186230533
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0270-1
