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Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasio...

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasio...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3195621033

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

About this item

Full title

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Journal of cancer research and clinical oncology, 2018-03, Vol.144 (3), p.415-430

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Autophagy is a catabolic process for degrading dysfunctional proteins and organelles, and closely associated with cancer cell survival under therapeutic, metabolic stress, hypoxia, starvation and lack of growth factors, contributing to resistance to therapies. However, the role of autophagy in breast cancer cells is not well understood. In the pres...

Alternative Titles

Full title

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3195621033

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3195621033

Other Identifiers

ISSN

0171-5216

E-ISSN

1432-1335

DOI

10.1007/s00432-017-2557-5

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