Organ defects of the Usp7 K444R mutant mouse strain indicate the essential role of K63-polyubiquitin...
Organ defects of the Usp7 K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation
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United States: Elsevier Limited
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English
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United States: Elsevier Limited
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K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquitinated USP7 serves as a scaffold to anchor HIF1α, CREBBP, the mediator complex, and the super elongation complex t...
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Full title
Organ defects of the Usp7 K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation
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TN_cdi_proquest_journals_3205381669
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3205381669
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ISSN
2319-4170
E-ISSN
2320-2890
DOI
10.1016/j.bj.2022.02.002
