Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironme...
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
About this item
Full title
Author / Creator
Barry-Hamilton, Vivian , Spangler, Rhyannon , Marshall, Derek , McCauley, Scott , Rodriguez, Hector M , Oyasu, Miho , Mikels, Amanda , Vaysberg, Maria , Ghermazien, Haben , Wai, Carol , Garcia, Carlos A , Velayo, Arleene C , Jorgensen, Brett , Biermann, Donna , Tsai, Daniel , Green, Jennifer , Zaffryar-Eilot, Shelly , Holzer, Alison , Ogg, Scott , Thai, Dung , Neufeld, Gera , Van Vlasselaer, Peter and Smith, Victoria
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Pathologically altered stromas are a common contributing factor to cancer progression and fibrogenesis. This report uncovers the role of LOXL2 in the creation and maintenance of the pathological microenvironment of human cancers and fibrotic diseases and presents the development of a LOXL2-specific antibody that shows therapeutic activity in tumor...
Alternative Titles
Full title
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
Authors, Artists and Contributors
Author / Creator
Spangler, Rhyannon
Marshall, Derek
McCauley, Scott
Rodriguez, Hector M
Oyasu, Miho
Mikels, Amanda
Vaysberg, Maria
Ghermazien, Haben
Wai, Carol
Garcia, Carlos A
Velayo, Arleene C
Jorgensen, Brett
Biermann, Donna
Tsai, Daniel
Green, Jennifer
Zaffryar-Eilot, Shelly
Holzer, Alison
Ogg, Scott
Thai, Dung
Neufeld, Gera
Van Vlasselaer, Peter
Smith, Victoria
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_749941862
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_749941862
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2208
