MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Contents
The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes...
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MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
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TN_cdi_proquest_journals_750427112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_750427112
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1193692
