Small-molecule inhibition of Wnt signaling through activation of casein kinase 1[alpha]
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1[alpha]
About this item
Full title
Author / Creator
Thorne, Curtis A , Hanson, Alison J , Schneider, Judsen , Tahinci, Emilios , Orton, Darren , Cselenyi, Christopher S , Jernigan, Kristin K , Meyers, Kelly C , Hang, Brian I , Waterson, Alex G , Kim, Kwangho , Melancon, Bruce , Ghidu, Victor P , Sulikowski, Gary A , Lafleur, Bonnie , Salic, Adrian , Lee, Laura A , Miller, David M and Lee, Ethan
Publisher
Cambridge: Nature Publishing Group
Journal title
Language
English
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Publisher
Cambridge: Nature Publishing Group
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More information
Scope and Contents
Contents
Wnt/b-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote b-catenin turnover, we identified an FDA-approved drug, pyrvinium, as a potent inhibitor of Wnt signaling (EC50 of ~10 nM). We show pyrvinium b...
Alternative Titles
Full title
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1[alpha]
Authors, Artists and Contributors
Author / Creator
Hanson, Alison J
Schneider, Judsen
Tahinci, Emilios
Orton, Darren
Cselenyi, Christopher S
Jernigan, Kristin K
Meyers, Kelly C
Hang, Brian I
Waterson, Alex G
Kim, Kwangho
Melancon, Bruce
Ghidu, Victor P
Sulikowski, Gary A
Lafleur, Bonnie
Salic, Adrian
Lee, Laura A
Miller, David M
Lee, Ethan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_759156111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_759156111
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.453
