Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and serves an antiapoptotic function in hepatocytes. K8-null mice develop colonic hyperplasia and colitis that are reversed after antibiotic treatment. To investigate the pathways that underlie the mechanism of colonocyte hyperplasia and the normalization of the colonic...
Alternative Titles
Full title
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_848011972
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_848011972
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1010833108
