Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
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Atlanta: Wiley Subscription Services, Inc
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English
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Atlanta: Wiley Subscription Services, Inc
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Contents
Poly(ADP-ribose) polymerase (PARP) is an attractive antitumor target because of its vital role in DNA repair. The homologous recombination (HR) DNA repair pathway is critical for the repair of DNA double-strand breaks and HR deficiency leads to a dependency on error-prone DNA repair mechanisms, with consequent genomic instability and oncogenesis. T...
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
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TN_cdi_proquest_journals_851268774
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_851268774
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ISSN
0007-9235
E-ISSN
1542-4863
DOI
10.3322/caac.20095
