Biodistribution and Dosimetry of In-111/Y-90-HuCC49[Delta]Ch2 (IDEC-159) in Patients with Metastatic...
Biodistribution and Dosimetry of In-111/Y-90-HuCC49[Delta]Ch2 (IDEC-159) in Patients with Metastatic Colorectal Adenocarcinoma
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Publisher
New Rochelle: Mary Ann Liebert, Inc
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English
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Publisher
New Rochelle: Mary Ann Liebert, Inc
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Background: CC49, an antibody (mAb) reactive to tumor-associated glycoprotein (TAG-72), has been extensively studied for radioimmunotherapy for colon cancer. Myelotoxicity has been dose-limiting because of prolonged circulation time in the plasma, and human anti-mouse antibody responses were observed in the majority of patients. A CH2 domain delete...
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Full title
Biodistribution and Dosimetry of In-111/Y-90-HuCC49[Delta]Ch2 (IDEC-159) in Patients with Metastatic Colorectal Adenocarcinoma
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TN_cdi_proquest_journals_854057930
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_854057930
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ISSN
1084-9785
E-ISSN
1557-8852
DOI
10.1089/cbr.2010.0864
