Rat Urinary Bladder Carcinogenesis by Dual-Acting PPAR [alpha]+[gamma] Agonists
Rat Urinary Bladder Carcinogenesis by Dual-Acting PPAR [alpha]+[gamma] Agonists
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New York: John Wiley & Sons, Inc
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Language
English
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Publisher
New York: John Wiley & Sons, Inc
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Contents
Despite clinical promise, dual-acting activators of PPAR α and γ (here termed PPAR α + γ agonists) have experienced high attrition rates in preclinical and early clinical development, due to toxicity. In some cases, discontinuation was due to carcinogenic effect in the rat urothelium, the epithelial layer lining the urinary bladder, ureters, and ki...
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Full title
Rat Urinary Bladder Carcinogenesis by Dual-Acting PPAR [alpha]+[gamma] Agonists
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TN_cdi_proquest_journals_857152323
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_857152323
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ISSN
1687-4757
E-ISSN
1687-4765
