Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocyti...
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of
DNMT3A
, which encodes a DNA methyltransferase, in 20% of cases.
Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the identification of somati...
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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
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TN_cdi_proquest_journals_861328379
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_861328379
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.788
