Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita
Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita
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New York, NY: Elsevier Inc
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English
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New York, NY: Elsevier Inc
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Pachyonychia congenita (PC) is a keratinizing disorder predominantly caused by mutations in keratin 6a (K6a) (∼50% of cases) or K6b, K16, or K17. One means of treating PC is identification of small-molecule inhibitors of PC-related keratins. Here, we cloned the human K6a promoter, and using a cell-based reporter gene assay, a chemical library was s...
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Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita
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TN_cdi_proquest_journals_862030155
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_862030155
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ISSN
0022-202X
E-ISSN
1523-1747
DOI
10.1038/jid.2011.41
