STIM1, PKC-[delta] and RasGRP set a threshold for proapoptotic Erk signaling during B cell developme...
STIM1, PKC-[delta] and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
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New York: Nature Publishing Group
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English
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New York: Nature Publishing Group
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Clonal deletion of autoreactive B cells is crucial for the prevention of autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterize a previously unrecognized Ca(2+)-driven pathway for activation of the kinase Erk, which was proapoptotic and biochemically distinct from Erk activation induced by di...
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STIM1, PKC-[delta] and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
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TN_cdi_proquest_journals_862810708
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_862810708
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2016
