Nanoparticles can cause DNA damage across a cellular barrier
Nanoparticles can cause DNA damage across a cellular barrier
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Author / Creator
Bhabra, Gevdeep , Sood, Aman , Fisher, Brenton , Cartwright, Laura , Saunders, Margaret , Evans, William Howard , Surprenant, Annmarie , Lopez-Castejon, Gloria , Mann, Stephen , Davis, Sean A. , Hails, Lauren A. , Ingham, Eileen , Verkade, Paul , Lane, Jon , Heesom, Kate , Newson, Roger and Case, Charles Patrick
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The increasing use of nanoparticles in medicine has raised concerns over their ability to gain access to privileged sites in the body. Here, we show that cobalt–chromium nanoparticles (29.5 ± 6.3 nm in diameter) can damage human fibroblast cells across an intact cellular barrier without having to cross the barrier. The damage is mediated by a novel...
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Full title
Nanoparticles can cause DNA damage across a cellular barrier
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TN_cdi_proquest_journals_869440305
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_869440305
Other Identifiers
ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/nnano.2009.313
