Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic targe...
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancerf
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Author / Creator
Giamas, Georgios , Filipovic, Aleksandra , Jacob, Jimmy , Messier, Walter , Zhang, Hua , Yang, Dongyun , Zhang, Wu , Shifa, Belul Assefa , Photiou, Andrew , Tralau-stewart, Cathy , Castellano, Leandro , Green, Andrew R , Coombes, R Charles , Ellis, Ian O , Ali, Simak , Lenz, Heinz-josef and Stebbing, Justin
Publisher
New York: Nature Publishing Group
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Language
English
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New York: Nature Publishing Group
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Contents
Giamas et al identify LMTK3 kinase as a regulator of ERα activity. LMTK3 exerts its effects through direct interaction and indirectly through regulation of PKC, AKT and FOXO3's effects on ERα transcription and stability. LMTK3 can modulate tamoxifen responses and is a poor prognostic factor in human breast cancer.
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Full title
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancerf
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TN_cdi_proquest_journals_870456368
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_870456368
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2351
