Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Human apolipoprotein E (apoE) is one of the major determinants in lipid transport, playing a critical role in atherosclerosis and other diseases. Binding to lipid and heparan sulfate proteoglycans (HSPG) induces apoE to adopt active conformations for binding to low-density lipoprotein receptor (LDLR) family. ApoE also interacts with beta amyloid pe...
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Full title
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
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TN_cdi_proquest_journals_889268428
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_889268428
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1106420108
