Crystal structure of the human thioredoxin reductase–thioredoxin complex
Crystal structure of the human thioredoxin reductase–thioredoxin complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx). T...
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Crystal structure of the human thioredoxin reductase–thioredoxin complex
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TN_cdi_proquest_journals_894707500
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_894707500
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms1382
