Sympathetic control of bone mass regulated by osteopontin
Sympathetic control of bone mass regulated by osteopontin
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Author / Creator
Nagao, Masashi , Feinstein, Timothy N , Ezura, Yoichi , Hayata, Tadayoshi , Notomi, Takuya , Saita, Yoshitomo , Hanyu, Ryo , Hemmi, Hiroaki , Izu, Yayoi , Takeda, Shu , Wang, Kathryn , Rittling, Susan , Nakamoto, Tetsuya , Kaneko, Kazuo , Kurosawa, Hisashi , Karsenty, Gerard , Denhardt, David T , Vilardaga, Jean-Pierre and Noda, Masaki
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The sympathetic nervous system suppresses bone mass by mechanisms that remain incompletely elucidated. Using cell-based and murine genetics approaches, we show that this activity of the sympathetic nervous system requires osteopontin (OPN), a cytokine and one of the major members of the noncollagenous extracellular matrix proteins of bone. In this...
Alternative Titles
Full title
Sympathetic control of bone mass regulated by osteopontin
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_journals_900805061
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_900805061
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1109402108
