Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered h...
Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The goal of cancer immunotherapy is the generation of an effective, stable, and self-renewing antitumor T-cell population. One such approach involves the use of high-affinity cancer-specific T-cell receptors in gene-therapy protocols. Here, we present the generation of functional tumor-specific human T cells in vivo from genetically modified human...
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Full title
Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
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TN_cdi_proquest_journals_912455278
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_912455278
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1115050108
