Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression fr...
Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice
About this item
Full title
Author / Creator
Quan, W. , Hur, K. Y. , Lim, Y. , Oh, S. H. , Lee, J.-C. , Kim, K. H. , Kim, G. H. , Kim, S.-W. , Kim, H. L. , Lee, M.-K. , Kim, K.-W. , Kim, J. , Komatsu, M. and Lee, M.-S.
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
Subjects
More information
Scope and Contents
Contents
Aims/hypothesis
The unfolded protein response (UPR) in endoplasmic reticulum (ER) and autophagy are known to be related. We investigated the role of autophagy in UPR of pancreatic beta cells and the susceptibility of autophagy-deficient beta cells to the ER stress that is implicated in the development of diabetes.
Methods
Rat insulin promo...
Alternative Titles
Full title
Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_912495919
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_912495919
Other Identifiers
ISSN
0012-186X
E-ISSN
1432-0428
DOI
10.1007/s00125-011-2350-y
