Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects...
Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
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New York: Springer Nature B.V
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English
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New York: Springer Nature B.V
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A fourth-generation pharmacokinetic/pharmacodynamic (PK/PD) model for receptor/genemediated effects of corticosteroids was developed. Male adrenalectomized Wistar rats received a 50 mg/kg iv bolus dose of methylprednisolone (MPL). Plasma concentrations of MPL, hepatic glucocorticoid receptor (GR) messenger RNA (mRNA) and GR density, tyrosine aminot...
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Full title
Fourth-Generation Model for Corticosteroid Pharmacodynamics: A Model for Methylprednisolone Effects on Receptor/Gene-Mediated Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
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TN_cdi_proquest_journals_916240038
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_916240038
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ISSN
1567-567X
E-ISSN
1573-8744
DOI
10.1023/A:1023233409550
