The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin
About this item
Full title
Author / Creator
Shao, Yong-Xian , Zhao, Peng , Li, Zhe , Liu, Ming , Liu, Peiqing , Huang, Min and Luo, Hai-Bin
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
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Scope and Contents
Contents
In our previous kinetics studies the natural products oroxylin and wogonin were shown to have strong biological affinity for, and inhibitory effects against, human cytochrome P450 1A2, with IC
50
values of 579 and 248 n
M
, respectively; this might lead to the occurrence of drug–drug interactions when co-administered clinically. However...
Alternative Titles
Full title
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_journals_921727230
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_921727230
Other Identifiers
ISSN
0175-7571
E-ISSN
1432-1017
DOI
10.1007/s00249-011-0785-1
