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Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels

Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_926582590

Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels

About this item

Full title

Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (9), p.3359

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major portal for the release of factors responsible for the anabolic effects of mechanical loading on bone formation and remodeling. However, little is known about how the Cx43 molecule responds to mechanical stimulation leading to the opening of the HC. Here, we demonstr...

Alternative Titles

Full title

Mechanical stress-activated integrin [alpha]5[Beta]1 induces opening of connexin 43 hemichannels

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_926582590

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_926582590

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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