Tubulin Stability and Decay: Mediation by Two Distinct Classes of IKP104-Binding Sites
Tubulin Stability and Decay: Mediation by Two Distinct Classes of IKP104-Binding Sites
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United States: Springer Nature B.V
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English
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United States: Springer Nature B.V
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IKP104, a novel antimitotic drug, has two classes of binding sites on bovine brain tubulin with different affinities. IKP104, by itself, enhances the decay of tubulin, but in the presence of colchicine or podophyllotoxin, it stabilizes tubulin instead of opening up the hydrophobic areas [Luduena et al. (1995), Biochemistry 34, 15751-15759]. Here, w...
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Tubulin Stability and Decay: Mediation by Two Distinct Classes of IKP104-Binding Sites
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TN_cdi_proquest_journals_963539286
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_963539286
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ISSN
0277-8033,1572-3887
E-ISSN
1573-4943
DOI
10.1023/A:1022579930546
