Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 pr...
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes
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Publisher
Germany: Elsevier GmbH
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Language
English
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Publisher
Germany: Elsevier GmbH
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Contents
The effects of Danshen and its active components (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on CYP2D6 activity was investigated by measuring the metabolism of a model CYP2D6 probe substrate, dextromethorphan to dextrorphan in human pooled liver microsomes. The ethanolic extract of crude Danshen (6.25–100μg/ml) decreased...
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Full title
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes
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TN_cdi_proquest_miscellaneous_1011538368
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1011538368
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ISSN
0944-7113
E-ISSN
1618-095X
DOI
10.1016/j.phymed.2012.01.005
