SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
In a mouse model of cannabinoid tolerance, persistent activation of the eCB pathway impairs eCB-mediated long-term depression (LTD) preferentially at connections to striatopallidal neurons. This is associated with a shift in behavioral control from goal-directed action to habitual responding; both LTD and behavioral changes were rescued by modulati...
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SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
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TN_cdi_proquest_miscellaneous_1014108421
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1014108421
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3022
