Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
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Author / Creator
Chen, Guo-Yun , Chen, Xi , King, Samantha , Cavassani, Karen A , Cheng, Jiansong , Zheng, Xincheng , Cao, Hongzhi , Yu, Hai , Qu, Jingyao , Fang, Dexing , Wu, Wei , Bai, Xue-Feng , Liu, Jin-Qing , Woodiga, Shireen A , Chen, Chong , Sun, Lei , Hogaboam, Cory M , Kunkel, Steven L , Zheng, Pan and Liu, Yang
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The sialic acid–dependent interaction of the co-inhibitory receptors CD24 and SiglecG prevents excessive inflammatory responses to pathogen infection. Chen
et al
. show that microbial sialidases exacerbate sepsis by disrupting this interaction and that sialidase inhibitors reduce mortality in an intestinal perforation mouse model of sepsis.
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Full title
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
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TN_cdi_proquest_miscellaneous_1017967643
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1017967643
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1846
