MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury...
MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice
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Publisher
Basingstoke: Elsevier Inc
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Language
English
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Publisher
Basingstoke: Elsevier Inc
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Murine double minute (MDM)-2, an E3 ubiquitin ligase, promotes cancer cell survival and growth, by degrading the cell cycle regulator p53. Antagonism of MDM2 by the small-molecule cis-imidazoline nutlin analogs is under current study for cancer therapy. To test whether MDM2 also promotes regenerative cell growth, we determined the effects of nutlin...
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MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice
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TN_cdi_proquest_miscellaneous_1018343228
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1018343228
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ISSN
0085-2538
E-ISSN
1523-1755
DOI
10.1038/ki.2011.482
