Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugate...
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
About this item
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Author / Creator
Shen, Ben-Quan , Xu, Keyang , Liu, Luna , Raab, Helga , Bhakta, Sunil , Kenrick, Margaret , Parsons-Reponte, Kathryn L , Tien, Janet , Yu, Shang-Fan , Mai, Elaine , Li, Dongwei , Tibbitts, Jay , Baudys, Jakub , Saad, Ola M , Scales, Suzie J , McDonald, Paul J , Hass, Philip E , Eigenbrot, Charles , Nguyen, Trung , Solis, Willy A , Fuji, Reina N , Flagella, Kelly M , Patel, Darshana , Spencer, Susan D , Khawli, Leslie A , Ebens, Allen , Wong, Wai Lee , Vandlen, Richard , Kaur, Surinder , Sliwkowski, Mark X , Scheller, Richard H , Polakis, Paul and Junutula, Jagath R
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen
et al.
show that the local chemical environment of the conjugation site influences the
in vivo
stability and efficacy of the modified antibodies.
The reactive thiol in cysteine is used for coupling maleimide linkers in the...
Alternative Titles
Full title
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
Authors, Artists and Contributors
Author / Creator
Xu, Keyang
Liu, Luna
Raab, Helga
Bhakta, Sunil
Kenrick, Margaret
Parsons-Reponte, Kathryn L
Tien, Janet
Yu, Shang-Fan
Mai, Elaine
Li, Dongwei
Tibbitts, Jay
Baudys, Jakub
Saad, Ola M
Scales, Suzie J
McDonald, Paul J
Hass, Philip E
Eigenbrot, Charles
Nguyen, Trung
Solis, Willy A
Fuji, Reina N
Flagella, Kelly M
Patel, Darshana
Spencer, Susan D
Khawli, Leslie A
Ebens, Allen
Wong, Wai Lee
Vandlen, Richard
Kaur, Surinder
Sliwkowski, Mark X
Scheller, Richard H
Polakis, Paul
Junutula, Jagath R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1020858540
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1020858540
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.2108
