An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The histone modification H3K9me3, the histone methyltransferase SUV39H1 and the H3K9me3-binding protein HP1α participate in maintaining the silent state of the two canonical T helper 1 cell signature genes (which encode interferon-γ and T-bet), ensuring T helper 2 lineage stability
in vitro
and
in vivo
; targeting this pathway has the p...
Alternative Titles
Full title
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
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TN_cdi_proquest_miscellaneous_1024936080
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1024936080
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11173
