Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment
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Author / Creator
Morgado, Isabel , Wieligmann, Karin , Bereza, Magdalena , Rönicke, Raik , Meinhardt, Katrin , Annamalai, Karthikeyan , Baumann, Monika , Wacker, Jessica , Hortschansky, Peter , Malešević, Miroslav , Parthier, Christoph , Mawrin, Christian , Schiene-Fischer, Cordelia , Reymann, Klaus G. , Stubbs, Milton T. , Balbach, Jochen , Görlach, Matthias , Horn, Uwe and Fändrich, Marcus
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Oligomers are intermediates of the β-amyloid (Aβ) peptide fibrillogenic pathway and are putative pathogenic culprits in Alzheimer's disease (AD). Here we report the biotechnological generation and biochemical characterization of an oligomer-specific antibody fragment KW1. KW1 not only discriminates between oligomers and other Aβ conformations, such...
Alternative Titles
Full title
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment
Authors, Artists and Contributors
Author / Creator
Wieligmann, Karin
Bereza, Magdalena
Rönicke, Raik
Meinhardt, Katrin
Annamalai, Karthikeyan
Baumann, Monika
Wacker, Jessica
Hortschansky, Peter
Malešević, Miroslav
Parthier, Christoph
Mawrin, Christian
Schiene-Fischer, Cordelia
Reymann, Klaus G.
Stubbs, Milton T.
Balbach, Jochen
Görlach, Matthias
Horn, Uwe
Fändrich, Marcus
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1030873974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1030873974
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1206433109
