Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The authors find that aged mice have decreased expression of the DNA methyltransferase Dnmt3a2 in the hippocampus. Rescue of Dnmt3a2 expression in aged mice reversed learning and memory deficits, whereas decreasing Dnmt3a2 expression in young mice impaired memory formation.
Cognitive abilities decline in normal aging, yet the underlying molecula...
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Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
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TN_cdi_proquest_miscellaneous_1034823534
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1034823534
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3151
