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Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosi...

Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1038605085

Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or Rb

About this item

Full title

Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or Rb

Author / Creator

Publisher

Netherlands

Journal title

Biogerontology (Dordrecht), 2000-01, Vol.1 (4), p.335-339

Language

English

Formats

Publication information

Publisher

Netherlands

More information

Scope and Contents

Contents

Human diploid fibroblasts (HDFs) inevitably undergo replicative senescence in culture after serial passages. Recent work indicates that early passage HDFs undergo irreversible growth arrest and develop features of senescence after being treated with oxidants and other agents. Senescence is usually measured by a decrease in DNA synthesis index and a...

Alternative Titles

Full title

Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or Rb

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1038605085

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1038605085

Other Identifiers

ISSN

1389-5729

E-ISSN

1573-6768

DOI

10.1023/A:1026590501344

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