LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
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Author / Creator
Matta, Samer , Van Kolen, Kristof , da Cunha, Raquel , van den Bogaart, Geert , Mandemakers, Wim , Miskiewicz, Katarzyna , De Bock, Pieter-Jan , Morais, Vanessa A. , Vilain, Sven , Haddad, Dominik , Delbroek, Lore , Swerts, Jef , Chávez-Gutiérrez, Lucía , Esposito, Giovanni , Daneels, Guy , Karran, Eric , Holt, Matthew , Gevaert, Kris , Moechars, Diederik W. , De Strooper, Bart and Verstreken, Patrik
Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Scope and Contents
Contents
LRRK2 is a kinase mutated in Parkinson’s disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2G2019S gain-of-kinase function, we show that LRRK2 affects synaptic en...
Alternative Titles
Full title
LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
Authors, Artists and Contributors
Author / Creator
Van Kolen, Kristof
da Cunha, Raquel
van den Bogaart, Geert
Mandemakers, Wim
Miskiewicz, Katarzyna
De Bock, Pieter-Jan
Morais, Vanessa A.
Vilain, Sven
Haddad, Dominik
Delbroek, Lore
Swerts, Jef
Chávez-Gutiérrez, Lucía
Esposito, Giovanni
Daneels, Guy
Karran, Eric
Holt, Matthew
Gevaert, Kris
Moechars, Diederik W.
De Strooper, Bart
Verstreken, Patrik
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1074765164
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1074765164
Other Identifiers
ISSN
0896-6273
E-ISSN
1097-4199
DOI
10.1016/j.neuron.2012.08.022
