The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The molecular control of germinal center selection is still being determined. Dalla-Favera and colleagues show that the cell-cycle regulator c-Myc is essential for B cell selection and reentry into the germinal center.
After antigenic challenge, B cells enter the dark zone (DZ) of germinal centers (GCs) to proliferate and hypermutate their immun...
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Full title
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
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TN_cdi_proquest_miscellaneous_1125237108
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1125237108
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2428
