Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
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Publisher
Dordrecht: SP MAIK Nauka/Interperiodica
Journal title
Language
English
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Publisher
Dordrecht: SP MAIK Nauka/Interperiodica
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Scope and Contents
Contents
This review describes the catalytic mechanism, substrate specificity, and structural peculiarities of alpha-ketoglutarate dependent nonheme iron dioxygenases catalyzing prolyl hydroxylation of hypoxia-inducible factor (HIF). Distinct localization and regulation of three isoforms of HIF prolyl hydroxylases suggest their different roles in cells. The...
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Full title
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
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Record Identifier
TN_cdi_proquest_miscellaneous_1178690160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1178690160
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ISSN
0006-2979,1608-3040
E-ISSN
1608-3040
DOI
10.1134/S0006297912100033
