Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Stabilization of ubiquitin's β1-β2 region by computational design and phage display, targeting both buried and surface residues, yields a ubiquitin variant that specifically inhibits the deubiquitinase USP7
in vitro
and in cells.
Protein conformation and function are often inextricably linked, such that the states a protein adopts define i...
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Full title
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
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TN_cdi_proquest_miscellaneous_1239054845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1239054845
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1134
